Objectives of the project:
1. Global analysis and computattional modelling of the infarcted heart.
1.1. Analysis of the multi-cellular response to ischemia/reperfusion in the heart.
1.1.1. Cell population profiling in the infarcted heart.
1.1.2. 3D-analysis of the cellular response in the infarcted heart.
1.2. Large-scale molecular data gathering in distinct cell populations of the infarcted heart.
1.2.1. Identification of transcriptomic changes.
1.2.2. Analysis of dynamic changes in the heart proteome induced by I/R.
1.2.3. Metabolome profiling of the infarcted heart.
1.3. Integrative Biology for computational modeling of the infarcted heart.
1.3.1. Mathematical modelling of the multi-cellular response to ischemia/reperfusion in the heart.
1.3.2. Large-scale data analysis.
1.3.3. Computational model of the infarcted heart.
2. New non-invasive imaging developments for the infarcted heart.
2.1. Implementation of PET-CT imaging to quantify the post-infarction myocardial damage.
2.2 New cardiac magnetic resonance imaging developments for the post-infarction heart.
2.2.1. Optimization of cardiac MRI image acquisition and reconstruction.
2.2.2. Combined molecular imaging and MRI.
3. New therapeutic strategies for the post-infarcted heart.
3.1. Validation of Potential biomarkers in human samples.
3.2. Nano-viral theranostics.
3.3. Gene therapy-based strategies to improve heart remodelling and repair.
3.3.1. Targeting cardiomyocytes.
3.3.2. Targeting macrophages and angiogenesis.
3.4. MicroRNA modulation in macrophages to improve heart remodelling and repair.

Publications:
[1] Fernández-Jiménez, Rodrigo, Javier Sánchez-González,
Jaume Agüero, Jaime García-Prieto, Gonzalo J. López-Martín, José M. García-Ruiz, Antonio Molina-Iracheta et al. "Myocardial edema after ischemia/reperfusion is not stable and follows a bimodal pattern: imaging and histological tissue characterization."
Journal of the American College of Cardiology 65, no. 4 (2015): 315-323.
[2] Fernández-Jiménez, Rodrigo, Jaime García-Prieto, Javier Sánchez-González,
Jaume Agüero, Gonzalo J. López-Martín, Carlos Galán-Arriola, Antonio Molina-Iracheta, Roisin Doohan, Valentin Fuster, and Borja Ibáñez. "Pathophysiology underlying the bimodal edema phenomenon after myocardial ischemia/reperfusion."
Journal of the American College of Cardiology 66, no. 7 (2015): 816-828.
[3] García-Álvarez, Ana, Inés García-Lunar, Daniel Pereda, Rodrigo Fernández-Jimenez, Javier Sánchez-González, Jesús G. Mirelis, Mario Nuño-Ayala et al. "Association of Myocardial T1-Mapping CMR With Hemodynamics and RV Performance in Pulmonary Hypertension."
JACC: Cardiovascular Imaging 8, no. 1 (2015): 76-82.
[4]
Bhavesh, R.; Lechuga-Vieco, A.V.; Ruiz-Cabello, J.; Herranz, F. T
1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis.
Nanomaterials 2015,
5, 1880-1890.
[5] Herranz, Fernando, Beatriz Salinas, Hugo Groult, Juan Pellico, Ana V. Lechuga-Vieco,
Riju Bhavesh, and J. Ruiz-Cabello. "Superparamagnetic nanoparticles for atherosclerosis imaging."
Nanomaterials 4, no. 2 (2014): 408-438.
[6] Groult, Hugo, Jesús Ruiz-Cabello, Juan Pellico, Ana V. Lechuga-Vieco,
Riju Bhavesh, Moreno Zamai, Elena Almarza et al. "Parallel Multifunctionalization of Nanoparticles: A One-Step Modular Approach for in Vivo Imaging."
Bioconjugate chemistry 26, no. 1 (2014): 153-160.
[7]
Polyxeni Gkontra, Magdalena M. Zak, Kerri-Ann Norton, Andres Santos, Aleksander S. Popel, and Alicia G. Arroyo, “A 3D fractal-based approach towards understanding changes in the infarcted heart microvasculature”, accepted for publication at Medical Image Computing and Computer Assisted Intervention
(MICCAI) 2015 (peer-reviewed conference)
[8]
Walter, Wencke, Fátima Sánchez-Cabo, and Mercedes Ricote. "
GOplot: an R package for visually combining expression data with functional analysis."
Bioinformatics (2015): btv300.